Urgent Updates | March 13, 2025

Mycoplasma pneumoniae infection in adult inpatients during the 2023–24 outbreak in France (MYCADO): a national, retrospective, observational study

This national, observational study highlighted unexpected, atypical radiological presentations, a high proportion of transfers to the ICU, and an association between severity and delayed administration of effective antibiotics. This should remind clinicians that no radiological presentation can rule out M pneumoniae infection and encourage them to reassess patients early after prescribing a β-lactam, or even to discuss prescribing macrolides as first-line treatment in the context of an epidemic. Full Access: The Lancet

Severity and Outcomes of Adult Respiratory Syncytial Virus Inpatient Compared with Influenza: Observational Study from Japan

RSV infections demonstrated comparable or greater health threats than influenza infections not only during hospitalization but also in long-term outcomes. The findings underscore the threat of RSV in adults, the impact on healthcare systems and the need for continued development of public health counter measures against RSV. Full Access: Infectious Disease

Five Engineering Advancements That May Help Solve the Growing Threat of Antimicrobial Resistance

Antimicrobial resistance (AMR) is increasingly seen as a “silent pandemic.” Following an optimistic report on future technologies to counter AMR, the engineering community stands to serve as the next critical collaborator. Leaders of the Engineering Research Visioning Alliance (ERVA) say that engineering-directed research can bridge the gap between fundamental principles and the tangible, scalable tools that patients and clinicians can actually use. Full Access: JAMA

Outbreak Investigation of Listeria monocytogenes: Frozen Supplemental Shakes

The FDA and CDC, in collaboration with state and local partners, are investigating illnesses in a multistate outbreak of Listeria monocytogenes infections linked to Lyons ReadyCare and Sysco Imperial Frozen Supplemental Shakes. As of February 24, 2025, a total of 38 people infected with the outbreak strain of Listeria monocytogenes have been reported from 21 states. Of the 38 people for whom information is available, 37 people have been hospitalized, and 12 deaths have been reported. Full Access: FDA

Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM

The rise of difficult-to-treat Candida infections is driven by new host factors and antifungal resistance. Pathogens, such as Candida auris (Candidozyma auris) and fluconazole-resistant Candida parapsilosis, pose serious global health risks. In this Review, experts provide updated recommendations for managing Candida infections, with detailed evidence summaries available in the appendix. Full Access: The Lancet