Urgent Updates | September 25, 2025

WHO, EMA, ACOG, and other medical societies: Acetaminophen Remains Safe Option in Pregnancy with no Autism Link

The WHO says there is no conclusive scientific evidence that using acetaminophen (paracetamol) during pregnancy is linked to autism. The causes of autism remain unclear and are believed to involve multiple factors; increased diagnosis and awareness partly explain rising prevalence. WHO reaffirms that vaccines do not cause autism, citing decades of high‑quality studies that have refuted earlier flawed claims. The statement emphasizes the importance of evidence‑based care, reducing stigma, and supporting autistic people and their families. Full Access: ACOG,  World Health Organization

Systemic Corticosteroid Use in Atopic Dermatitis: A Position Paper to Inform Safer Clinical Practice and Policy

The position paper emphasizes that while corticosteroids can provide short-term relief during acute flares, their routine or prolonged use poses significant safety risks, including rebound flares and long-term adverse effects. The paper recommends limiting systemic corticosteroids to rare, short-term situations (such as bridging to other systemic therapies or treating severe acute flares) and stresses the importance of transitioning to safer, evidence-based alternatives like biologics and JAK inhibitors. It also calls for clearer clinical guidelines and policy measures to reduce inappropriate prescribing, promote education, and support safer long-term management of AD. Full Access: Journal of Investigative Dermatology 

Adaptation And Pilot Implementation of a Validated, Electronic Real-Time Clinical Decision Support Tool for The Care of Pneumonia Patients In 12 Utah Urgent Care Centers

The AHRQ Dean Report details the pilot of ePneumonia, a clinical decision support tool used in 12 Utah urgent care clinics to improve pneumonia diagnosis and treatment. Early results show modest clinician uptake and highlight challenges with usability and integration. The tool aims to reduce unnecessary antibiotic use and emergency referrals by improving diagnostic accuracy and aligning care with guidelines. Preliminary data suggest improved documentation and a trend toward more guideline-concordant care, though further evaluation is needed to assess long-term impact and patient outcomes. Full Access: AHRQ

CDC Report Finds Sharp Rise in Dangerous Drug-Resistant Bacteria

There has been a dramatic increase (over 460%) in U.S. infections from NDM‑producing carbapenem‑resistant Enterobacterales (NDM‑CRE) between 2019 and 2023.These infections include pneumonia, bloodstream, urinary tract, and wound infections, which are extremely difficult to treat and associated with high rates of morbidity and mortality. The surge is driven in part by gaps in infection control in healthcare settings, limited diagnostic testing capacity, and delayed detection and treatment. CDC is urging healthcare providers to improve testing to identify the specific resistance mechanism, select treatments appropriately, and strengthen prevention and control practices. Full Access: CDC