WORLD HEALTH ORGANIZATION DECLARES GLOBAL HEALTH EMERGENCY OVER MONKEYPOX OUTBREAK
The rapidly spreading monkeypox outbreak represents a global health emergency – the World Health Organization’s highest level of alert. The WHO label – a “public health emergency of international concern (PHEIC)” – is designed to trigger a coordinated international response and could unlock funding to collaborate on sharing vaccines and treatments.
Full Access: Reuters
SYSTEMATIC REVIEW AND META-ANALYSIS OF ACUTE TREATMENTS FOR EPISODIC MIGRAINE IN ADULTS
New—and surprising—ways to approach migraine pain. This randomized, single-center, double-masked, crossover trial compared timolol maleate ophthalmic solution 0.5% with placebo among patients ages 12 or older presenting with a diagnosis of migraine. The primary outcome was a reduction in pain score. The primary outcome was achieved in 82% timolol-treated migraines, compared to 14% placebo-treated migraines (P < .001). Timolol, 0.5%, in solution applied to the eye has been shown to achieve 80% to 90% β-blockade in 10 to 15 minutes. Intranasal administration achieves β-blockade as fast as intravenous injection and therefore is the most effective method of delivering timolol, 0.5%, solution for acute migraine.
Full Access: JAMA
EFFICACY AND SAFETY OF CIPROFLOXACIN PLUS FLUOCINOLONE ACETONIDE AMONG PATIENTS WITH ACUTE OTITIS EXTERNAL
In this randomized clinical trial including 493 patients, ciprofloxacin plus fluocinolone was not superior to either agent alone for the primary outcome of therapeutic cure. A faster resolution of otalgia, superiority in sustained microbiological response, and superiority in the microbiological outcome were noted with ciprofloxacin plus fluocinolone compared with fluocinolone or ciprofloxacin alone.
Full Access: JAMA
NEW YORK DETECTS CASE OF VACCINE-DERIVED POLIO
Health officials on Thursday reported the detection of a case of vaccine-derived polio in a resident of Rockland County, New York, which is north of New York City. According to the state health department, testing done at a state lab and confirmed by the CDC showed that the virus is a vaccine strain Sabin type 2, which indicates that transmission occurred from someone who received an oral polio vaccine. There has not been a case of wild polio in the U.S. since 1979, according to the CDC.
Full Access: Healio