Incidence of Out-of-Hospital Cardiac Arrest on a Post-holiday Weekday
A nationwide South Korean cohort study of 203,471 adult out‑of‑hospital cardiac arrest (OHCA) cases found that the first weekday after a holiday had a 9% higher incidence of OHCA compared with other weekdays. The increased risk was particularly notable after ≥2 consecutive holiday days. Temporal analysis showed that this elevated incidence was linked to the transition from holiday routines (e.g., behavioral changes, stress) back to workdays. The findings suggest a period of heightened cardiovascular vulnerability in the post-holiday transition, extending beyond the holiday itself. Clinical implications include the need for enhanced emergency medical services preparedness, targeted public health messaging around holiday periods, and potentially closer monitoring or preventive strategies for high‑risk patients during post-holiday weekdays. Full Access: JAMA
More than 80% Of Physicians Use AI Professionally: AMA Survey
A new survey finds that over 80% of U.S. physicians now use AI professionally, a significant increase from previous years. Physicians report that AI tools are increasingly integrated into workflows, especially for charting, discharge instructions, coding, and communication tasks. However, use for clinical decision‑making or diagnosis remains more cautious, with clinicians prioritizing supportive rather than autonomous AI roles. Clinical implications: include potential reductions in workload and burnout, faster access to evidence summaries, improved efficiency, and a need for robust governance, training, liability guidelines, and oversight as AI becomes more embedded in practice. Full Access: AMA
Acetaminophen (Paracetamol) or Opioid Analgesia Added to Ibuprofen for Children’s Musculoskeletal Injury. Two Randomized Clinical Trials
A JAMA randomized trial found that adding acetaminophen or hydromorphone to ibuprofen did not significantly improve pain relief for children with acute musculoskeletal injuries. Hydromorphone increased adverse events, while acetaminophen added no meaningful benefit. Clinical implications: This supports using ibuprofen alone as first-line analgesia and discourages routine opioid or combination therapy, promoting safer pain management in pediatric emergency care. Full Access: JAMA
FDA Approves Secukinumab for Pediatric Patients 12 Years and Older with HS
The U.S. Food and Drug Administration approved Secukinumab for the treatment of moderate-to-severe Hidradenitis Suppurativa in pediatric patients aged 12 years and older, expanding therapeutic options for a chronic inflammatory condition that often begins around puberty and can cause painful nodules, wounds, and permanent scarring. Clinical implications: This approval provides clinicians with a targeted biologic option for adolescents with moderate-to-severe HS, potentially allowing earlier intervention and improved disease control. Early treatment may reduce long-term complications such as scarring, disability, and psychosocial burden associated with untreated or poorly managed HS. Full Access: HCP