The College of Urgent Care Medicine
Urgent Updates are highlights of guidelines from other groups, reviewed by Urgent Care physicians. These highlights represent the actual intent of these articles and how they relate to the practice of Urgent Care medicine.
Respiratory Adverse Events of Weight-Loss Drugs: A Systematic Review and Meta-Analysis This systematic review and meta-analysis pooled 123 studies evaluating respiratory adverse events of weight-loss drugs largely in general populations, with only one study specific to asthma patients. Liraglutide, semaglutide, tirzepatide, and naltrexone-bupropion showed no increased respiratory adverse events versus...
>> Read MorePharmacologic Treatment for Migraine Prevention in Adults Practice Guideline Recommendations: Report of the AAN Guidelines Subcommittee and the American Headache Society The AAN and American Headache Society released an updated practice guideline (first since 2012) on pharmacologic migraine prevention in adults, based on a systematic review through June 2024. The...
>> Read MoreThe Effectiveness of Nirsevimab on Antibiotic Use in Children Using Target Trial Emulation This target trial study showed Nirsevimab was associated with a 14.4% reduction in antibiotic prescribing for outpatient acute respiratory tract infections. It also showed a 40.3% reduction in antibiotic prescribing for outpatient bronchiolitis. Most strikingly, there was...
>> Read MoreEffects of a Diagnostic Stewardship Intervention to De-Implement Widespread Use of a Rapid Respiratory Multiplex PCR Test. This retrospective study evaluated a diagnostic stewardship intervention to reduce widespread, unrestricted use of a rapid multiplex respiratory PCR panel. The health system implemented a selective use strategy that removed the RPP order...
>> Read MoreEmpirical Antibiotic Prophylaxis Versus Culture-Directed Enhanced Prophylaxis for Prevention of Urinary Tract Infection After Flexible Ureteroscopy in Children: A Randomized Controlled Trial In this single-center RCT, 140 children (ages 4–16) with kidney or ureteral stones who received preoperative ureteral stents were randomized to standard empirical antibiotic prophylaxis (IV ceftriaxone before...
>> Read MoreCyclospora First Deaths: Expert Explains Why Cases Are So Difficult to Trace and What Infection Preventionists Should Know Michigan health officials confirmed the first two deaths tied to the largest US Cyclospora outbreak on record, both in patients with significant underlying conditions worsened by cyclosporiasis and dehydration. The outbreak has...
>> Read MoreSurveillance of Cyclosporiasis Since May 1, 2026, CDC has received reports of 4,173 laboratory-confirmed domestic cases of cyclosporiasis and is aware of more than 7,400 additional cases that are not yet laboratory confirmed and require further investigation and analysis. CDC, FDA and public health officials in several states are investigating...
>> Read MoreThe College of Urgent Care Medicine is committed to ensuring Urgent Care clinicians are ready to identify and respond to emerging infectious disease threats. As part of this mission, the Clinical Response Committee has developed a curated set of resources on Ebola virus disease and Cyclospora infection — covering both...
>> Read MoreAntiviral Therapies for Adults with Mild to Moderate COVID-19 Infection This JAMA article reviews updated recommendations for outpatient COVID-19 antiviral treatment, focusing on identifying patients at highest risk for severe disease. Early antiviral therapy remains most beneficial for older adults and those with significant risk factors for progression. Treatment decisions...
>> Read MoreWest Nile virus season starts early – Current Data West Nile virus activity is monitored by the CDC through the ArboNET surveillance system, with data updated every 1–2 weeks during mosquito season. Early-season case counts are typically low but increase throughout the summer as mosquito activity rises. These surveillance efforts...
>> Read MoreAcute Severity Versus Long-term Morbidity: Uncoupling the Roles of RSV and HRV in Childhood Respiratory Disease This retrospective cohort study compared RSV and HRV in hospitalized children with acute lower respiratory tract infections, analyzing 722 cases with 36-month follow-up. RSV was associated with greater acute illness severity (more pneumonia, fever,...
>> Read MoreRapid Respiratory Microbiological Point-of-Care Testing and Antibiotic Use in Primary Care – A Randomized Clinical Trial The primary outcome — same-day antibiotic prescribing — was identical in both groups at 45%, demonstrating no overall benefit of RM-POCT. The authors conclude that an RM-POCT testing only for viruses and atypical bacteria is...
>> Read MoreWHO Announces the Development of Recommendations on New Oral Antibiotics for the Treatment of Gonorrhea The WHO announced the development of new clinical recommendations for emerging oral antibiotics to treat gonorrhea amid rising global antimicrobial resistance and declining effectiveness of current standard therapies. The focus includes novel agents such as...
>> Read MorePsilocybin in the Treatment of Cocaine Use Disorder – A Randomized Clinical Trial In this randomized, quadruple-blind trial, 40 adults with cocaine use disorder received either a single dose of psilocybin or active placebo, combined with structured psychotherapy. Participants treated with psilocybin had significantly more cocaine-abstinent days, higher rates of...
>> Read MoreNIH-Funded Study Lays Foundation for Antibody-Based Measles Treatment. Researchers identified the first comprehensive group of human antibodies capable of neutralizing the measles virus, targeting both the hemagglutinin (H) and fusion (F) proteins. Several antibodies demonstrated potent antiviral activity in animal models, with one reducing viral levels to undetectable levels even...
>> Read MoreRapid Respiratory Microbiological Point-of-Care Testing and Antibiotic Use in Primary Care – A Randomized Clinical Trial This randomized clinical trial evaluated whether rapid multiplex respiratory microbiological point-of-care testing (RM-POCT) in primary care could reduce antibiotic prescribing for patients with acute respiratory tract infections. Among 552 patients, the intervention did not...
>> Read MoreAdjunctive Betamethasone Treatment of Hypoxemic Adults Hospitalized with Mycoplasma Pneumoniae Community-Acquired Pneumonia: An Open-Label, Multicenter, Randomized, Controlled Trial This study suggests that adding corticosteroids to standard antibiotic therapy may improve clinical outcomes, particularly in severe CAP, by reducing inflammation and disease progression. The benefit appears most pronounced in patients with...
>> Read MoreConsumer Understanding of Skin Concerns With an AI-Powered Informational Tool This study evaluated if AI-based dermatology tools improve how consumers interpret skin conditions and make care decisions. In a large survey study of over 2,300 participants, use of an AI application significantly increased users’ ability and confidence in identifying skin...
>> Read More