MATERNAL HYPERTENSIVE DISORDER OF PREGNANCY AND MORTALITY IN OFFSPRING FROM BIRTH TO YOUNG ADULTHOOD: NATIONAL POPULATION BASED COHORT STUDY
All 2 437 718 individuals live born in Denmark, 1978-2018, with follow-up from date of birth until date of death, emigration, or 31 December 2018, whichever came first. The primary outcome was all cause mortality. Secondary outcomes were 13 specific causes of death in offspring from birth to young adulthood (age 41 years). Maternal HDP, particularly eclampsia and severe pre-eclampsia, is associated with increased risks of overall mortality and various cause specific mortalities in offspring from birth to young adulthood.
Full Access: BMJ
RECURRENCE OF SYMPTOMS FOLLOWING A 2-DAY SYMPTOM FREE PERIOD IN PATIENTS WITH COVID-19
Recurrence of symptoms after finishing treatment for COVID-19 with nirmatrelvir-ritonavir (Paxlovid) has become increasingly recognized. Using daily symptoms data from a prospective trial, researchers found the natural history of untreated COVID-19 was variable and undulating. Over one-third of participants who experienced symptom resolution for at least 2 consecutive days within the first 4 to 5 weeks of COVID-19 symptoms reported recurrent symptoms. Consistent with an earlier report, results in persons with untreated COVID-19 shows that recurring symptoms are common among those who initially improve, but these recrudescent symptoms do not portend progression to severe COVID-19.
Full Access: JAMA
TRENDS IN THE INCIDENCE OF SPONTANEOUS SUBARACHNOID HEMORRHAGES IN THE UNITED STATES, 2007–2017
In this retrospective cohort study, the average annual age/sex-standardized incidence of SAH in cases per 100,000 population was 11.4, but incidence was significantly higher in women (13.1) compared to men (9.6) p <0.001. Incidence also increased with age in both sexes. Non-traumatic SAH incidence in the US increased over the last decade predominantly in middle-aged men and elderly men and women. Incidence is disproportionately higher and increasing in Black patients while that in other races and ethnicities did not change significantly over time.
Full Access: Neurology
TUBERCULOSIS DEATHS AND DISEASE INCREASE DURING THE COVID-19 PANDEMIC
An estimated 10.6 million people fell ill with tuberculosis (TB) in 2021, an increase of 4.5% from 2020, and 1.6 million people died from TB (including 187 000 among HIV positive people), according to the World Health Organization’s 2022 Global TB report. The burden of drug-resistant TB (DR-TB) also increased by 3% between 2020 and 2021, with 450 000 new cases of rifampicin-resistant TB (RR-TB) in 2021.This is the first time in many years an increase has been reported in the number of people falling ill with TB and drug resistant TB.
Full Access: WHO