Early Childhood Antibiotics and Chronic Pediatric Conditions: A Retrospective Cohort Study
A retrospective cohort study using electronic health records data from the United Kingdom (1987-2020) showed children receiving multiple antibiotic courses between birth and age 2 were more likely to develop asthma, food allergies, allergic rhinitis, and intellectual disability. However, risks of most autoimmune, neurodevelopmental, and psychiatric conditions studied were minimal following early-childhood antibiotic exposure. Full Access: The Journal of Infectious Diseases
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Integrated Phase I Pharmacokinetics and Pharmacodynamics of Epinephrine Administered Through Sublingual Film, Autoinjector, or Manual Injection
Sublingual delivery of epinephrine achieved pharmacokinetic and pharmacodynamic results that were comparable with manual intramuscular injection and autoinjectors. These results indicate that sublingual epinephrine may be an effective, needle-free alternative for treating type I allergic reactions such as anaphylaxis. Full Access: Annals of Allergy, Asthma and Immunology
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Antibiotic Candidate for Lyme Disease Boosts Hope
Researchers screened nearly 500 FDA approved compounds and identified piperacillinopens as a good candidate for clearing the bacteria causing Lyme disease specifically without disrupting the rest of the microbiome. Full Access: Science Translational Medicine
Buprenorphine Treatment in Pregnancy and Maternal-Infant Outcomes
In this cohort study of 14 463 maternal-infant dyads, treatment with buprenorphine was associated with a lower probability of severe maternal morbidity, preterm birth, and neonatal intensive care unit admissions compared to no treatment, highlighting the importance of treatment expansion in the US. Full Access: JAMA
