Machine Learning for Diagnosis Of Myocardial Infarction Using Cardiac Troponin Concentrations
Researchers developed machine learning models that integrate cardiac troponin concentrations at presentation or on serial testing with clinical features and compute the Collaboration for the Diagnosis and Evaluation of Acute Coronary Syndrome (CoDE-ACS) score (0–100) that corresponds to an individual’s probability of myocardial infarction. CoDE-ACS used as a clinical decision support system has the potential to reduce hospital admissions and have major benefits for patients and health care providers. Full Access: Nature
Head-to-Head Comparison of 25 Migraine Meds Reveals Top Options
Researchers analyzed 25 acute medications. They employed a two-level nested logistic regression model to analyze the odds of treatment effectiveness of each medication by adjusting concurrent medications and the covariance within the same user. The final analysis included more than 3.1 million migraine attacks among 278,000 users globally. Ibuprofen, triptans, ergots, and antiemetics had the highest efficacy. Full Access: Medscape
FDA Approves Seres Therapeutics’ Pill for Deadly C. Difficile Infections
The drug, branded as Vowst, was approved for treating 18 years and older for recurrent Clostridioides difficile (C. diff) infections (CDI), generally caused by prolonged use of antibiotics, which wipe out friendly colon bacteria and can cause potentially fatal diarrhea and inflammation of the colon. Full Access: Medscape
WHO Report Shows Gaps in Pipeline Of Antibiotic Treatments To Combat AMR
Antimicrobial resistance (AMR) is part of the top ten public health threats globally, and the World Health Organization’s annual report shows the AMR R&D pipeline to be insufficient to fight the spread of antibiotic resistance. Full Access: PMLive
