Urgent Updates | March 10

A woman dies every two minutes due to pregnancy or childbirth: UN agencies

New data show major setbacks for maternal health in many parts of the world, highlighting stark disparities in healthcare access

Every two minutes, a woman dies during pregnancy or childbirth, according to the latest estimates released in a report by United Nations agencies. The report, which tracks maternal deaths nationally, regionally and globally from 2000 to 2020, shows there were an estimated 287 000 maternal deaths worldwide in 2020. In two of the eight UN regions – Europe and Northern America, and Latin America and the Caribbean – the maternal mortality rate increased from 2016 to 2020, by 17% and 15% respectively. Full Access: WHO


Doxy PEP Does Not Lower Risk of STIs in Cisgender Women

The benefits of doxycycline postexposure prophylaxis (Doxy PEP) in preventing the transmission of sexually transmitted infections (STIs) in men and transgender women do not appear to extend to cisgender women, who have disproportionately high rates of infection in many regions. Full Access: Medscape


Effect of an Intranasal Corticosteroid on Quality of Life and Local Microbiome in Young Children With Chronic Rhinosinusitis – A Randomized Clinical Trial

In this open-label randomized clinical trial including 63 children, the group treated with intranasal mometasone presented better clinical improvement, a greater increase in nasopharyngeal microbiome richness, and a greater decrease in nasal ILC3 abundance compared with the control group. Intranasal corticosteroids may be clinically effective in the treatment of pediatric chronic rhinosinusitis and may help correct sinonasal dysbiosis.

This randomized clinical trial demonstrated that treatment with an INC improved the quality of life of children with CRS and had a significant effect on increasing sinonasal biodiversity. Full Access: JAMA


Physicians Are More Burned Out Than Ever—Here’s What Can Be Done About It

Despite a growing body of evidence supporting a systemic approach to health care worker well-being, we’ve seen some alarming trends in burnout and turnover in health care. Suggestions to address burnout includes creating a “culture of well-being.” It lays out 7 priority areas for action: creating positive work and learning environments, investing in assessment and research, supporting mental health, addressing regulatory and policy barriers, using effective technology, adopting well-being as an institutional value, maintaining a diverse, inclusive health care workforce. Full Access: JAMA