Urgent Updates | June 22

Here’s What to Know About Xylazine, aka Tranq, the Animal Tranquilizer Increasingly Found in Illicit Fentanyl Samples
Veterinarians have used this sedative and pain reliever for half a century, but it has never been approved for human use. And yet, it is increasingly being detected in the illicit US drug supply from coast-to-coast—typically combined with fentanyl or heroin—and in drug overdoses.
Full Access: JAMA

Management of Pilonidal Disease – A Review
Pilonidal disease is associated with significant physical and psychosocial morbidity. Optimal treatments will minimize disease and treatment-associated morbidity. There is a need for standardization of definitions used to characterize pilonidal disease and its outcomes to develop evidence-based treatment algorithms.
Full Access: JAMA

Notes from the Field: Pediatric Intracranial Infections — Clark County, Nevada, January–December 2022
In October 2022, the Southern Nevada Health District (SNHD) was notified of a higher-than-expected number of pediatric patients hospitalized with intracranial abscesses; similar concerns were previously reported nationally. This rare infection is associated with significant morbidity.
Full Access: CDC

Kidney Ultrasonography After First Febrile Urinary Tract Infection in Children – A Systematic Review and Meta-analysis
In this systematic review and meta-analysis of 29 studies and 9170 children, the prevalence of abnormalities detected on kidney ultrasonography was 22.1%. Of the 8 studies with 2569 children that reported clinically important abnormalities, the prevalence was 3.1%. This study results suggest that 1 in 4 to 5 children with a first febrile UTI will have a urinary tract abnormality detected on kidney ultrasonography and 1 in 32 will have an abnormality that changes clinical management.
Full Access: JAMA