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Heat Waves Associated with Increased Risk of Preterm Birth in The U.S.
A new investigation confirmed the link to early deliveries at a massive scale, in a large cohort study capturing over half of the births that occurred in the United States between 1993 and 2017. In this cohort study, preterm and early-term birth rates increased after heat waves, particularly among socioeconomically disadvantaged subgroups. Extreme heat events have implications for perinatal health and may be exacerbated by worsening climate. Full Access: JAMA
A Stratified Approach for Managing Patients with Low Back Pain in Primary Care (SPLIT Program): A Before-and-After Study
Over the cohort study period of 6 months, patients in the SPLIT program showed significantly greater improvements in back-related disability, perceived effect of treatment, and health-related quality of life compared with usual care group. Full Access: Annals of Family Medicine
Anti-TSLP Therapy Reduces Inflammation in Moderate to Severe Asthma
Patients with asthma saw a 23% reduction in FeNO with treatment. Most adverse events were mild, with no serious events. Three patients across both study groups developed anti-drug antibodies. Tezepelumab is the first and only biologic that has demonstrated efficacy for a broad population of patients with severe asthma across phenotypes and irrespective of biomarker levels including bronchial epithelial cells, allergic status and fractional exhaled nitric oxide. Full Access: Helio
Tattoos as a Risk Factor for Malignant Lymphoma: A Population-Based Case–Control Study
In this case–control study researchers identified all incident cases of malignant lymphoma diagnosed between 2007 and 2017 in individuals aged 20–60 years. The risk of lymphoma was highest in individuals with less than two years between their first tattoo and the index year. The risk decreased with intermediate exposure duration (three to ten years) but increased again in individuals who received their first tattoo ≥11 years before the index year. We found no evidence of increasing risk with a larger area of total tattooed body surface. The risk associated with tattoo exposure seemed to be highest for diffuse large B-cell lymphoma and follicular lymphoma. Full Access: The Lancet