Urgent Updates | February 1, 2024

Excess Mortality Following a First and Subsequent Osteoporotic Fracture: A Danish Nationwide Register-Based Cohort Study on The Mediating Effects of Comorbidities

The highest mortality risk was found in the month immediately following both index and subsequent fracture. The combination of index and subsequent fractures at different skeletal sites had a substantial impact on the risk of mortality. Full Access: BMJ

Development and Validation of the Phoenix Criteria for Pediatric Sepsis and Septic Shock

In this international, multicenter, retrospective cohort study including more than 3.6 million pediatric encounters, a novel score, the Phoenix Sepsis Score, was derived and validated to predict mortality in children with suspected or confirmed infection. The new data-driven criteria for pediatric sepsis and septic shock based on measures of organ dysfunction had improved performance compared with prior pediatric sepsis criteria. Full Access: JAMA

First Trimester Use of Buprenorphine or Methadone and the Risk of Congenital Malformations

In this cohort study of 9514 pregnancies with first-trimester buprenorphine exposure and 3846 with methadone exposure, the prevalence of congenital malformations overall and several malformation subtypes was lower among pregnant individuals treated with buprenorphine compared with methadone, except for gastrointestinal malformations. Full Access: JAMA

Most Firearm Deaths in US Children Happen While They Play

Unintentional injuries are the leading cause of death for children between the ages of 1 and 17 years, with about 3% of these fatalities due to firearm injuries. Nearly two-thirds of the children killed were playing with the weapon or showing it to one another when it went off, according to a recent analysis of data collected by the US Centers for Disease Control and Prevention on about 1300 unintentional firearm fatalities between 2003 and 2021. Full Access: JAMA