Trends in Prenatal Exposure to Antiseizure Medications Over the Past Decade
A Nationwide Study
A recent French registry study (2013–2021) observed a total of 55,801 pregnancies with antiseizure medication (ASM) exposure during the first trimester. Over the decade, use of safer ASMs—notably lamotrigine and levetiracetam—rose by ~30%, while exposure to high-risk ASMs like valproate/valpromide fell by over 80%. However, carbamazepine and topiramate exposures declined only marginally, and newer agents with uncertain risk (e.g. pregabalin, gabapentin) saw increased utilization. Socioeconomically disadvantaged women remained disproportionately more exposed to higher-risk medications. Overall, the study highlights a promising shift toward prescribing lower-risk ASMs during pregnancy—but underscores ongoing concerns about persistent use of drugs with known teratogenic potential and disparities in exposure. Full Access: American Academy of Neurology
The JAMA review highlights that diverticulitis is increasingly managed in outpatient settings, with many cases not requiring antibiotics. For uncomplicated diverticulitis, supportive care alone is often sufficient, as antibiotics do not speed recovery or reduce complications. CT imaging is key for diagnosis, while complicated cases may require hospitalization, antibiotics, or surgery. This reflects a shift toward more conservative, evidence-based management. Full Access: JAMA
When Patients Arrive with Answers
A family physician reflects on the evolving clinician‑patient dynamic in which patients come armed with medical advice generated by AI tools like ChatGPT. The essay explores the tension between this wealth of pre‑arranged information and the patient’s deeper need to feel truly heard and understood. Through narrative medicine, Dr. Sundar illustrates how listening empathetically—rather than debating content—can deepen trust, honor patient autonomy, and enhance therapeutic relationships. Full Access: JAMA
Regular Use of Opioids and Dementia, Cognitive Measures, and Neuroimaging Outcomes Among UK Biobank Participants With Chronic Non-Cancer Pain
A UK Biobank cohort study examined the relationship between regular opioid use for chronic non‑cancer pain and long‑term cognitive outcomes, including dementia risk, cognitive performance, and brain structure. Researchers found that participants who regularly used opioids had an 18% higher risk of developing all‑cause dementia compared to those who used non‑opioid pain medications. The risk was even greater among users of strong opioids, who demonstrated up to a 70% increased risk of dementia and a 150% increased risk of vascular dementia. Full Access: Journal of the Alzheimer’s Association