PCR TESTING OF NON-GENITAL SITES FOR TREPONEMA PALLIDUM
Samples from non-genital sites i.e., from peripheral blood, urine, pharynx, and anus were most likely to be positive in those patients with secondary syphilis. Moreover, Treponema Pallidum DNA (TP-DNA) was frequently positive in sites without overt evidence of infection, suggesting that such locations represent occult sources of syphilis transmission. The authors propose that TP-DNA testing of non-genital sites could be a potential screening tool for syphilis.
Full Access: NJEM
LONG-TERM BRAIN HEALTH IS IMPACTED BY SEVERITY OF COVID-19
The study covered in this summary was published in medRxiv.org as a preprint and has not yet been peer reviewed. Follow-up of hospitalized patients with COVID-19 shows that the severity of acute COVID-19 is associated with chronic cerebrovascular consequences for cognitive function and mental well-being. Changes in cerebrovascular integrity may be due to either direct viral invasion or the inflammatory milieu because of infection.
Full Access: Medscape
CDC RELEASES UPDATED DRAFT GUIDANCE ON OPIOID PRESCRIBING
CDC has released a draft update of its current Clinical Practice Guidelines for Prescribing Opioids for pain management. The updated recommendations are now open for public comment via the Federal Register’s website through April 11. The CDC noted that the updated guidance provides “evidence-based recommendations” for treatment of adults with acute, subacute, or chronic pain. It does not include guidance for managing pain related to sickle cell disease, cancer, or palliative care.
Full Access: CDC