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TREATMENT OF MULTIDRUG-RESISTANT GRAM-NEGATIVE BACILLI CLINICAL PRACTICE GUIDELINES (ESCMID, 2021)
Guidelines for the treatment of multidrug-resistant gram-negative bacilli were published in December 2021 by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) with the endorsement of the European Society of Intensive Care Medicine (ESICM).
For bloodstream infection (BSI) and severe infection due to 3GCephRE, a carbapenem (imipenem or meropenem) is recommended. For BSI without septic shock, ertapenem may be used instead. Stepdown targeted therapy is good clinical practice after carbapenems once patients are stabilized. Full Access: Medscape
TWO POWERFUL DRUGS NOW ADDING TO US OVERDOSE CRISIS
Emerging reports show that two “little-known” drugs are making lethal new contributions to America’s drug overdose crisis. Para-fluorofentanyl and metonitazene are being seen more often by medical examiners looking into overdose deaths. They often are taken with — or mixed with — illicit fentanyl, the drug mainly responsible for the more than 100,000 U.S. overdose deaths in the last year.
Full access: Medscape
THE SILENT EPIDEMIC: MENTAL HEALTH OF CLINICIANS
In surveys among the general populace since the start of the pandemic, 40% of respondents reported struggling with mental health, and claims of burnout rose 52%.
With the COVID-19 pandemic, vulnerability and wellness became much more difficult to achieve. Long hours and high demand created the perceived need for strength and infallibility among clinicians. Nearly every state in the union has a program dedicated to the wellness of health care professionals who struggle with mental health and substance use disorders (SUDs).
Full Access: Doximity
OMICRON SUBVARIANT 1.5 TIMES MORE CONTAGIOUS THAN OMICRON
The Omicron subvariant, known as BA.2, spreads about 1.5 times faster than the original Omicron strain. BA.2 is more contagious, but it doesn’t appear to increase hospitalizations or reduce how well the vaccine works. The Omicron subvariant has been detected in at least 29 states in the U.S. and 56 countries. The U.S. has detected 188 infections, with the worldwide total nearing 25,000.
Full Access: Medscape